Noncardiac causes of aortic emboli are mainly related to aneurysmal disease, atherosclerosis of the aortic wall, or paradoxical emboli of the venous circulation.1Furthermore, several coagulation disorders such as protein C and protein S deficiency, hyperhomocysteinemia, antithrombin-III deficiency, and elevated factor VIII levels have also been linked to mural thrombus formation in the aorta.2The majority of these cases present with symptoms of peripheral embolization. The gene discussed is PROS1; the disease is hyperinsulinemic hypoglycemia, familial, 4.