AFP and neoplasm: As we can see in Figure 2A–2I, up-regulated CENPL was distributed in patients with family history (Yes vs. No, p = 0.011), vascular invasion (No vs. Yes, p = 0.032), new tumor event (p = 0.033), risk factor (R1 vs. R2 vs. R3 vs. R4, p = 0.043), with tumor (p = 0.006), high AFP (AFP < 20 vs. 20 ≤ AFP < 400 vs. AFP ≥ 400, p = 2.655e−08) as well as unfavorable histologic grade (G1-2 vs. G3-4, p = 4.234e−10), clinical stage (Stage I−II vs. Stage III−IV, p = 0.008) and topography (T) stage (T1-2 vs. T3-4, p = 0.005).