Angiotensin receptor neprilysin inhibitor (ARNI)-Sacubitril/valsartan, which could balance renal blood flow and improve glomerular filtration rate, is recommended as a replacement for renin-angiotensin blocker to further reduce the risk of heart failure hospitalization and death in ambulatory patients with reduced left ventricular ejection fraction [17, 18]. This evidence concerns the gene REN and heart failure.