The coronary artery disease patients who died had higher occurrence rate of acute myocardial infarction (65% and 34%, p<0.001), higher occurrence rate of gastrointestinal bleeding (15.0% and 5.6%, p =0.029), worsening renal function (72% and 25%, p<0.001), heart failure (85.0% and 37.4%, p <0.001), and severe coronary artery stenosis (27.5% and 13.4%, p=0.022), lower medication rate of renin-angiotensin blocker (17.5% and 34%, p=0.036), lower rate of percutaneous transluminal coronary intervention (20.0% and 34.4%, p=0.033) in comparison with the living. This evidence concerns the gene REN and heart failure.