There was higher mortality (30.2% and 5.2%, p<0.001), higher occurrence rate of heart failure (76.0% and 28.9%, p<0.001) and severe coronary artery stenosis (22.9% and 11.8%, p=0.013), lower rate of percutaneous coronary intervention (23.9% and 36.0%, p=0.036), lower medication rate of renin-angiotensin blocker (23% and 35%, p=0.044) in the renal function deterioration group compared with patients who had preserved renal function. This evidence concerns the gene REN and heart failure.