The PALB2 gene was recently classified as a high risk breast cancer susceptibility gene in Caucasian women, with 53% cumulative risk to age 80 years and 7-fold relative risk for female breast cancer7,32, which was comparable to the breast cancer risk of the BRCA2 gene in Caucasian women8,13,33. The gene discussed is PALB2; the disease is breast carcinoma.