TP53 and breast cancer: After excluding the 3 patients with Li-Fraumeni syndrome, the TP53 gene was still significantly associated with a high risk of breast cancer in Chinese women (OR: 15.2, 95% CI: 4.6–50.1, P = 2.00 × 10−9), which suggested that women with TP53 pathogenic variants but without a family history of Li-Fraumeni syndrome still had a high risk of breast cancer.