In this context, the accumulation of α‐ketoglutarate (αKG) and of intramitochondrial oxygen favor the degradation of hypoxia‐inducible factor 1α (HIF‐1α), the key regulator of hypoxic responses, thus reducing cancer growth both in vitro and in vivo [6, 11, 20, 21]. This evidence concerns the gene HIF1A and cancer.