The neologism oncojanus was coined by our group in 2011 to describe MT‐ND1 as a gene, encoding the CI ND1 subunit, that is able to differently impact on tumor progression depending on both its mutation type and load, a concept that was subsequently reinforced by correlating MT‐ND1 mutations with diverse degrees of CI dysfunction [5, 6]. Here, MT-ND1 is linked to neoplasm.