TP53 and neoplasm: Overall, a role for p53 in CI‐defective neoplasms warrants investigation, as it may reveal crucial in the adaptive responses that allow survival or persistence of cancer cells during a metabolic crisis, such as in the case of indolent oncocytomas with a disassembled CI, where this tumor suppressor does not appear to be ever the main driver of tumorigenesis (Fig. 1).