FTH1 and Sepsis: For example, H-ferritin facilitates cell adaptation to malaria, and inhibition of H-ferritin leads to increased cell susceptibility with elevated oxidative stress and tissue damage.17 Similarly, the activity of H-ferritin on cytosolic iron sequestration is critical for cell tolerance to sepsis.16 In the same direction, H-ferritin knockout mice experience increased inflammatory response, higher bacterial load, and reduced survival after infection with mycobacterium tuberculosis.18