CA9 and glaucoma: Acetazolamide (AAZ) and methazolamide (MZA) are two approved drugs employed in the treatment of glaucoma, ethoxzolamide (ETZ) is a diuretic that inhibits CAs in proximal renal tubules, and SLC-0111 (SLC) is a CA inhibitor with high selectivity for the CA IX isoform and is currently in Phase Ib/II clinical trials as an anticancer/antimetastatic agent (McDonald et al., 2020 ▸).