A combination of NK‐1R antagonists with chemotherapy/radiotherapy was reported to reduce the side effects of conventional cancer therapy and improved the antitumor effects.[24, 33] In this study, we demonstrated that treatment with NK‐1R antagonists not only induced apoptosis and inhibited tumor growth but also improved the efficacy of the chemotherapeutic drug 5‐fluorouracil in CRC. This evidence concerns the gene TACR1 and colorectal carcinoma.