Not only in colon cancer presented in this study, we recently reported that blockage of NK‐1R in myeloid leukemia cells elicited a rapid ER calcium release, which mediates the cytotoxicity of NK‐1R antagonist.[12] Therefore, it is likely that induction of ER stress is a key mechanism of action mediating the cytotoxicity of NK‐1R antagonists in tumor cells. This evidence concerns the gene TACR1 and malignant colon neoplasm.