Indeed, hyperactivation of the ERK signaling by expressing constitutively active harvey rat sarcoma viral oncogene homolog (HRAS)G12V increased the c‐Myc protein abundance (Figure 3C) and critically protected the human CRC cells from SR140333‐induced cell death (Figure 3D), strongly supporting that ERK signaling mediates the response to NK‐1R antagonists in human CRC cells. Here, MYC is linked to colorectal carcinoma.