Calcium release is a key feature of ER stress, and disruption of ER function and accumulation of unfolded proteins in the ER lumen result in the activation of an unfolded protein response (UPR).[18] Therefore, we hypothesized that blocking NK‐1R in human colon cancer cells will leads to the development of ER stress. Here, TACR1 is linked to malignant colon neoplasm.