PARP1 and colorectal carcinoma: Moreover, treatment with SR140333 resulted in an increase in the abundance of proapoptotic proteins including BCL2‐associated X (BAX), cleaved Caspase 3, and cleaved poly (ADP‐Ribose) polymerase 1 (PARP1), and a decrease in the expression of antiapoptotic protein B‐cell CLL/Lymphoma 2 (BCL‐2)(Appendix A1 and Figure S2D, Supporting Information), indicating that blocking NK‐1R activates the intrinsic apoptotic pathways in human CRC cells.