Significant associations between BRD3 rs2427964 and worse OS were found in adenocarcinoma (aHR = 2.78, 95% CIs = 1.77–4.35, P = 8× 10−6) but not in squamous cell carcinoma (aHR= 1.35, 95% CIs = 0.81–2.25, P = 0.25; P < 0.05 for the homogeneity test; Table S5). Here, BRD3 is linked to adenocarcinoma.