SIRT5 and hepatocellular carcinoma: Most importantly, vimentin undergoes various functionally important PTMs, including acetylation (Kim et al., 2006), and one sirtuin family member, SIRT5, was found to physically interact with and deacetylate vimentin at K120 and thus influence the EMT process in hepatocellular carcinoma cells (Guo et al., 2018).