PTPN11 and cancer: SHP2 is a large phosphatase encoded by PTPN11 gene, with pivotal role in regulating several physiological aspects of the cell, as cell cycle control, differentiation, and migration,5 and in controlling oncogenic molecular pathways such as Jak/STAT,6, 7 PI3K/AKT,8, 9 and RAS/Raf/MAPK,10, 11, 12 thus representing an attractive target for cancer therapies.