More importantly, we found that the WNT pathway inhibitor XAV-939 blunted the increase in sphere number promoted by CCNP in the three cell lines tested (p-values vs. CCNP without XAV-939: A549 = 0.0235; LoVo = 0.0115; MCF7 = 0.0571) (Fig. 4C), supporting the notion that CCNP regulates cancer cell stemness through WNT pathway activation. The gene discussed is CCNP; the disease is cancer.