SOX2 and cancer: Thus, to investigate whether these results are representative of CCNP in cancer in general, we extracted data from the Depmap portal (depmap.org/portal), which contains gene expression profiles of 1304 cell lines of different histological types (Expression Public 20Q2) [32].When cancer cells with the lowest and highest quarters of CCNP expression were grouped, the subset with a higher CCNP expression exhibited a significantly higher expression of OCT4 and SOX2 (p < 0.0001) (Fig. 2D), indicating that these correlations can be observed in several cancer models.