SOSTDC1 and central nervous system cancer: This was the case for SEMA5A (FDR = 0.0855), DRD2 (FDR = 0.00623) and SOSTDC1 (FDR = 0.0234), which have all been found to act as tumor suppressors in pancreas cancer, glioma, non-small cell lung cancer and thyroid cancer [49–54].