FZD10 and lung cancer: In contrast to most other studies, one study of genome-wide methylation in lung cancer found that FZD10 is hypermethylated and downregulated in tumors compared to normal tissue and FZD10 has low expression in medulloblastomas compared to normal cerebellum [107, 136].The presence of FZD10 expression in early lesions of multiple cancers but lack of expression in normal adult tissues highlight a key characteristic of chemoprevention targets.