FZD8 and breast carcinoma: Silencing FZD8 with miRNAs to inhibit FZD8 activity decreased EMT associated proteins TCF4, MMP7, and nuclear β-catenin in both breast cancer and colorectal cancer [92, 125].While FZD8 has primarily been investigated in aggressive and metastatic tumors, several studies point to a role for FZD8 in premalignant lesions.