First, it was shown that RNA interference (RNAi)-mediated depletion of DCAF2 caused apoptosis in the 12 tumor cell lines examined, but not in 6 non-transformed cell lines, suggesting that cancer cells are dependent on the functional targeting of Cdt1 by CRL4DCAF2 at levels much higher than normal cells [70]. The gene discussed is CDT1; the disease is cancer.