Surgery to remove symptomatic neurofibromas has its limitations in feasibility and resultant morbidities, particularly intraoperative blood loss and long term neurologic deficits.23 MEK inhibitors have been proposed as treatment for neurofibromas but was interestingly found to be less effective in DNL than in PN.24 This retrospective review of whole-body MRI showed that thermal ablation of DNL with MR-HIFU may be feasible alternative to medical therapy for or surgical resection of symptomatic DNL. Here, MAP2K7 is linked to neurofibroma.