Identificationof FOSL1 binding to COL1A1 and COL1A2 was insightfulbecause FOSL factors are known to regulate collagen production inother cell types.76,77 Additionally, changes in collagenprotein levels are correlated with the development of rheumatoid arthritisand osteoarthritis.70,78 This suggests a potential involvementof FOSL1 in the incidence of human autoimmunity. This evidence concerns the gene COL1A2 and osteoarthritis.