HDAC2 is a global modifierof gene expression that suppresses IL-17 transcription and therebyreduces colitis scores.73 In contrast,PCBP1 is a ferritin iron regulator that promotes Th17 pathogenicityand autoimmunity.43,87 These findings indicate thatFOSL1 may control the lineage by associating with both the activatorand repressor complexes. This evidence concerns the gene PCBP1 and Autoimmunity.