HDAC2 is a global modifierof gene expression that suppresses IL-17 transcription and therebyreduces colitis scores.73 In contrast,PCBP1 is a ferritin iron regulator that promotes Th17 pathogenicityand autoimmunity.43,87 These findings indicate thatFOSL1 may control the lineage by associating with both the activatorand repressor complexes. Here, HDAC2 is linked to colitis.