In conclusion, silencing miRNA-30a-5p may protect against pulmonary fibrosis, alleviate inflammatory cell infiltration, enhance pulmonary and biochemical functions and prevent the further progression of inflammation, and ultimately affect the progression of pulmonary fibrosis through activating Beclin-1 to regulate autophagy, so the present research provides a novel theoretical basis of prevention and treatment of pulmonary fibrosis. This evidence concerns the gene BECN1 and pulmonary fibrosis.