Pathways that have been reported to be related to liver cancer also include “metallothioneins bind metals” (R-HSA:5661231) [30], “RNA Polymerase I Promoter Opening” (R-HSA:73728) [31], and “SIRT1 negatively regulates rRNA expression” (R-HSA:427359) [32]. This evidence concerns the gene SIRT1 and liver cancer.