MT-ND4 and neurodegenerative disease: In the energy metabolism category of oxidative phosphorylation (MT-ND3, MT-ND2, MT-CO1, ND6, MT-ND4L, MT-ATP8, MT-ND4, ND5, COX3, MT-CYB, ND1, ATP6V1G3, MT-CO2, and ATP6), the neurodegenerative diseases category, including Parkinson disease (MT-ND3, MT-ND2, MT-CO1, ND6, MT-ND4L, MT-ND4, ND5, COX3, MT-CYB, ND1, MT-CO2, and ATP6) and Huntington disease, and the retrograde category of the nervous system related to endocannabinoid signaling, were enriched in the SA and FA groups (P < 0.05) (Figure 6 and Supplementary Table 1).