In T84 cells, which are derived from human colorectal carcinoma and thought to be a potential alternative to Caco-2 cells (59), the expression of CYP3A4 is controversial (60), while expressions of CYP2B6, CYP2C9, CYP2C19, and CYP2E1 are lacking (61). Here, CYP2E1 is linked to colorectal carcinoma.