This is because a prior report shows quite convincingly that RIPK3-mediated necroptosis is not a discernible contributor to the acute infarct size in a mouse model of acute MI induced by coronary artery ligation, although RIPK3 deficiency did attenuate the chronic post-MI maladaptive cardiac remodeling (32). The gene discussed is RIPK3; the disease is myocardial infarction.