TGFB1 and atherosclerosis: Additionally, simvastatin attenuated 1-Palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POVC) inducing EndMT, by suppressing oxidative stress and TGF-β/SMAD signaling, suggesting that simvastatin could potentially be used in treating atherosclerosis (97).