Under cardiac hypertrophy, H19 acts as a miR-675 precursor to regulate the expression of miR-675 downstream gene VDAC1 and CM apoptosis in cytoplasm (Figure 3) (12); In nucleus, H19 regulates PRC2 occupancy on the promoters of DIRAS3 and Tescalcin to repress cardiac hypotrophy (Figure 3) (6, 56). This evidence concerns the gene H19 and cardiac hypertrophy.