After transient cerebral ischemia injury (1 h ischemia and 3 days of reperfusion), JQ1 significantly reduces infarct volume, neurological deficit score, and glial activation in ischemic mice, along with significantly decreased levels of pro-inflammatory factors IL-1β, IL-6, IL-18, and TNF-α (Zhou et al., 2019). The gene discussed is TNF; the disease is transient ischemic attack.