KRAS and acute myeloid leukemia: In human K-RAS-mutant leukaemia cell lines and in acute myeloid leukaemia (AML) cells, K-RAS4A is also expressed, and Zhao and colleagues showed that cells harbouring mutations at the palmitoylation site of oncogenic K-RAS4A (i.e., palmitoylation-defective mutant K-RAS4AG12D/C180S) present a reduction in leukemogenicity potential.