F10 and chronic kidney disease: Lastly, the Factor XA Inhibition in REnal Patients with Non-valvular Atrial Fibrillation-Observational Registry (XARENO) (NCT02663076) is an observational prospective study that will compare CKD progression with rivaroxaban, VKA or no anticoagulation in patients with CKD stages 3–4 and NVAF.