DNMT1 and neoplasm: MiR-29b-3p is known to critically affect cancer progression by functioning as a tumor suppressor (Yan et al., 2015), and it targets several DNA methyltransferases (DNMTs, including DNMT1, DNMT3B, etc.)and regulates members of the DNA demethylation signaling pathway, leading to the downregulation of global DNA methylation in malignant cells (Garzon et al., 2009b).