From a functional point of view, the microbiota of individuals with high abundances of the Prevotella Cluster and Pathogen Cluster might influence the development of CRC through modulating the expression of immunoinflammatory response genes (i.e., CXCL1), which has been shown to increase the survival of cancerous cells and promote angiogenesis in CRC(Wang et al., 2006; Acharyya et al., 2012; Flemer et al., 2017). The gene discussed is CXCL1; the disease is colorectal carcinoma.