IFNG and neoplasm: Furthermore, intra-tumoral gene expression analysis of T-cell activation markers showed an increase in the expression of genes functionally linked to anti-tumor immune response, including Flt3 (Bhardwaj et al., 2020; Cueto and Sancho, 2021), Cd40lg (Curran et al., 2015), IFNγ (Gerber et al., 2013), and Il7 (Pellegrini et al., 2009; Figure 3I).