CD40 and neoplasm: Strikingly, in UDP-treated tumors comparison, we found an increase in the expression of genes known to be positively involved in T-cell-mediated anti-tumor response, including Flt3, Cd40lg, Ifng, Nos2, Il2ra, Il1b, Dpp4, Cd40, and Il7. Conversely, we found a decrease in the expression of genes such as Trp53, Map3k7, Prkcq, and Cdkn1a (Figure 3I).