Indeed, Wan et al. recently showed that the triggering of P2Y6 receptor by UDP treatment in gastric cancer cells caused an increase in Ca2+ levels, through store-operated calcium entry (SOCE), and consequently inhibited β-catenin in calcium-dependent manner and cell proliferation, leading to the reduction of tumor growth (Wan et al., 2017). Here, P2RY6 is linked to neoplasm.