PRKCB and cancer: In 2014, Wallace et al. (2014) found that macrophage infiltration into breast cancer tumor sites is reduced in PRKCB knockout mice, suggesting that PRKCB is crucial for macrophage infiltration which has been associated with poor outcomes in EwS and other cancers (Fujiwara et al., 2011; Yang J. et al., 2015; Yagi et al., 2019).