EZH2 and neoplasm: An enhanced macrophage infiltration into EwS tumors following the transfer of PRKCB and CCND1 transcripts could promote tumor growth (Fujiwara et al., 2011), potentially by increasing the density of macrophages in tumors to amplify the immunosuppressive effects of their proinflammatory cytokines triggered by EZH2 and DKK2 (Figure 2).