EWSR1 and neoplasm: EZH2 is a histone methyltransferase trimethylating histone H3 at Lys 27, and a transcriptional target of EWS-FLI1, which can form the Polycomb repressive complex 2 associated with the transcriptional repression of tumor suppressors such as p14ARF and p16INK4a (Varambally et al., 2002; Viré et al., 2006).