EZH2 and neoplasm: Consistent with previous studies, the mRNA of enhancer of zeste homolog 2 (EZH2) was detected in bioengineered tumor-derived exosomes, at a level similar to the one of plasma samples from EwS patients, but at a higher level than in exosomes secreted from monolayer cell lines (Miller et al., 2013; Villasante et al., 2016).