BRCC3 and urinary bladder cancer: Moreover, we investigated the BRCC3 mRNA and protein levels in bladder cancer-derived cell lines and the immortalized normal uroepithelial cell line SV-HUC1, and found that 6 out of 8 cancer cell lines showed BRCC3 expression upregulation, compared with SV-HUC1 (Figures 1E,F).