RUNX3 and myocardial infarction: In cardiac, Kcnq1ot1 recruits DNA methyltransferase 1 (DNMT1) to the RUNX3 promoter region and inhibit Runx3 expression, regulating the proliferation and apoptosis of CMEC and induces inflammatory response during myocardial infarction (Wang et al., 2019).