In cardiac, Kcnq1ot1 recruits DNA methyltransferase 1 (DNMT1) to the RUNX3 promoter region and inhibit Runx3 expression, regulating the proliferation and apoptosis of CMEC and induces inflammatory response during myocardial infarction (Wang et al., 2019). The gene discussed is DNMT1; the disease is myocardial infarction.