lncRNA H19 was significantly upregulated in the infarct area and reaches an exceptionally high level at post-MI day 4, then competes with COL1A1 to form the H19-YB-1 complex under hypoxia, resulting in decreased COL1A1 expression, thus preventing ECM deposition and cardiac remodeling (Choong et al., 2019). The gene discussed is H19; the disease is myocardial infarction.