Experiments show that RIPK1 and RIPK3 participate in H2O2-induced cardiomyocytes necrosis, miR-873 suppresses the translation of RIPK1/RIPK3 and inhibits RIPK1/RIPK3-mediated necrotic cell death in cardiomyocytes, which reduces myocardial infarct size upon ischemia/reperfusion (I/R) injury in the animal model. Here, RIPK3 is linked to infarction.