It has been shown that expression of both ICAM-1 and VCAM-1 on intimal and medial SMCs is prominent in fibrous plaques and advanced atherosclerotic lesions and that expression of VCAM-1 correlates with intimal neovessels and mononuclear cell infiltration (Kasper et al., 1996; O’Brien et al., 1996). This evidence concerns the gene ICAM1 and Atherosclerotic lesion.