Citing as rationale the fact that mRNA vaccines induce an immune response through toll-like receptor 3 (TLR3) activation, and TLR3 activation has been linked to adverse placentally-mediated pregnancy outcomes in rodent models such as decidual arteriopathy, growth restriction, preterm delivery, and fetal loss (Zhang et al., 2007; Koga et al., 2009; Thaxton et al., 2013; Pardi et al., 2018; Baines et al., 2020), another study of 84 pregnant people receiving the COVID-19 mRNA vaccines in pregnancy examined the placenta for lesions detectable on H&E histopathology (Shanes et al., 2021). The gene discussed is TLR3; the disease is COVID-19.