Conversely, genes significantly enriched in CT1/2 included innate immune response genes (BPIFB1, PELI3), fractalkine (CX3CL1), genes related to mucosal epithelial integrity (TFF3, CLDN10, MUC5B, LAMB1, RIPK4), genes related to neoplastic invasion (CTSK, KLK11, UCA1), and few related to tumor suppression (S100A14). The gene discussed is CTSK; the disease is neoplasm.