Although real-time blood glucose monitoring systems, automated insulin delivery equipment (artificial pancreatic islets), pancreas transplantation and cell therapy were developed to treat T1DM, their applications are limited due to supply constraints (based on donors) and the need for chronic immunosuppression (El-Khatib et al., 2017; Shapiro et al., 2017; Weisman et al., 2017). The gene discussed is INS; the disease is type 1 diabetes mellitus.