In the same line of the observations, the increase of cis-vaccenate would decrease the production of anti-inflammatory palmitoleic acid (Schirmer et al., 2016), leading to the increase of inflammatory cytokines like TNF-alpha required for the oral cancer stemness and aggressiveness (Lee et al., 2012; Krishnan et al., 2014). The gene discussed is TNF; the disease is lip and oral cavity carcinoma.