The consequences of this IL-1 over-production include (1) an increase in the phosphorylation of NF-кB inhibitor (IкB), thus freeing NF-кB known to be involved in melanoma development (93) and (2) activation of stress-activated protein kinase/c-Jun N-terminal kinase (JNK) identified as a key factor in melanoma progression (94). This evidence concerns the gene MAPK8 and melanoma.