MITF/MITF: Hallmark of the proliferative melanoma signature (12, 14, 16)SOX10/SOX10: Upstream TF of MITF (14, 16, 27, 30, 32, 33)PAX3/PAX3: Upstream TF of MITF (27, 30)CREB/CREB1: Upstream TF of MITF (27, 30)LEF1/LEF1: β-catenin co-factor, suppresses TCF4 expression (34)ZEB2/ZEB2: The ZEB1-to-ZEB2 switch promotes the proliferative switch (35–38). The gene discussed is ZEB1; the disease is melanoma.