IPRES shares similarities with the invasive melanoma gene signature, including AXL, ROR2, WNT5A, EGFR and PDGFRA, as well as some other phenotype switching-associated genes, such as TWIST2, MMPs, ANGPT2, IGFBP-6, SNAI1, CCL2 (146, 152, 202). Here, WNT5A is linked to melanoma.