RASSF5 and breast cancer: With regard to RASSF5 (also called NORE1), this gene encodes at least three distinct isoforms and is clearly regarded as a Ras effector and tumor suppressor, and its methylation has been found in a variety of tumor cell lines (including breast) and solid tumors (78–80), while the prognostic value of RASSF5 in breast cancer has hardly been reported.