Contrarily, although RASSF2 hypermethylation predicts a worse prognosis in squamous cervical cancer (76), nasopharyngeal carcinoma, gastric cancer and Ewing sarcoma, it has also been shown as an independent indicator of better prognosis (77) in breast cancer, which is inconsistent with our finding that high RASSF2 levels might be a protective prognostic factor in TNBC. This evidence concerns the gene RASSF2 and breast carcinoma.