CD274 and neoplasm: For example, tumor-infiltrating lymphocytes (TILs) in the tumor and stroma have shown an important prognostic value in TNBC, and more importantly TILs have also been identified as an indicator of response not only to neoadjuvant or adjuvant chemotherapy but also to anti-PD-1 or anti-PD-L1 antibodies in patients with TNBC (23–29).