We constructed a novel seven-gene signature (B3GALT5-AS1, DNER, CSN1S1, KIF5A, SIX3, NOTUM, and CPS1) and a combined prognostic model integrating a seven-gene signature with patient age and tumor size to quantify the likelihood of distant metastasis in lymph node-negative TNBC. Here, SIX3 is linked to neoplasm.