Another relevant systematic review (27) did not perform a formal meta-analysis on the diagnostic accuracy of the markers for CNS lymphoma in blood and CSF, and focused on various markers at the same time including CXCL13, interleukins-6, -8, and -10, soluble CD19, and so on, not just miRNAs. The gene discussed is CXCL13; the disease is primary central nervous system lymphoma.