Furthermore, EZH2 c.1544A>G, KMT2C c.7447G>T, ABL1 c.2986A>C, AXL c.460A>C, CDH1 c.383A>C, MED12 c.6401A>C, ERBB2 c.3307A>C, NTRK1 c.662G>C, BRD4 c.2319A>C, and TSC2 c.889T>G only occurred in ctDNA, and KMT2B c.7297+2T>G, KEAP1 c.971T>G, GATA3 c.412T>G, and GATA3 c.368A>C only occurred in tumor tissue. This evidence concerns the gene TSC2 and neoplasm.