Although there is no literature report on the impact of EZH2 c.1544A>G and CCND1 c.839A>T on liver cancer, these mutations are pathogenic, and the scores were 0.99 and 0.94 respectively according to the Catalogue of Somatic Mutations in Cancer (COSMIC) database (https://cancer.sanger.ac.uk/cosmic). The gene discussed is EZH2; the disease is liver cancer.