Moreover, ossification, collagen metabolic process, syndecan interactions, platelet activation, signaling and aggregation, cell-substrate adhesion, endodermal cell differentiation, response to growth factor, blood vessel development, proteoglycans in cancer, regulation of insulin-like growth factor (IGF) transport and uptake, and other pathways were also involved in the regulation of ADAM12-interacting genes (Figure 8A). The gene discussed is ADAM12; the disease is cancer.