Fatty acid synthesis depends on acetyl-CoA, and normal cells generated through the Krebs cycle can meet the demand of basic cellular functions, but mutations of stearoyl-CoA desaturase 1 (SCD1), fatty acid synthase (FASN), and acetyl-CoA carboxylase (ACC) in ccRCC can lead to the emergence of a large number of abnormal pathways for the synthesis of acetyl-CoA and synthetic fatty acid (FA), which are ultimately stored in the form of lipid droplets in the cytoplasm (24, 59, 60) (Figure 2). Here, SCD is linked to nonpapillary renal cell carcinoma.