To dig deeper into the role of the JAK2/STAT3/HIF-1/VEGFA signaling axis in GC, we utilized the JAK2 inhibitor LY2784544 (1 μM) and HIF-1 inhibitor SYP-5 (10 μM) in AGS and MKN45 cells with CALM2 overexpression. The gene discussed is VEGFA; the disease is gastric cancer.