On the contrary, published data on the pathobiology and the clinical significance in NSCLC of the surface receptors CD40 (tumor necrosis factor receptor superfamily member 5), BAFFR (tumor necrosis factor receptor superfamily member 13C), and LTβR (tumor necrosis factor receptor superfamily member 3), which mainly leads to signal transduction through the NF-κB alternative pathway, are limited. The gene discussed is CD40; the disease is non-small cell lung carcinoma.