Low MMP14 expression was observed in adrenocortical carcinoma (ACC), BLCA, glioblastoma multiforme (GBM), HNSC, KIRC, brain lower grade glioma (LGG), LIHC, LUAD, mesothelioma (MESO), ovarian serous cystadenocarcinoma (OV), and pancreatic adenocarcinoma (PAAD), and OS in THCA was positively related to prognosis. The gene discussed is MMP14; the disease is bladder transitional cell carcinoma.