Low MMP14 expression was observed in adrenocortical carcinoma (ACC), BLCA, glioblastoma multiforme (GBM), HNSC, KIRC, brain lower grade glioma (LGG), LIHC, LUAD, mesothelioma (MESO), ovarian serous cystadenocarcinoma (OV), and pancreatic adenocarcinoma (PAAD), and OS in THCA was positively related to prognosis. This evidence concerns the gene MMP14 and pancreatic adenocarcinoma.