• Suppresses the growth of mouse Nf2-/- schwannoma allografts and human meningioma and NF1-/- MPNST xenografts at 1.5 mg/kg• Bioavailability (mice): IP ~100%, oral ~1.7%• Lung toxicity in dogs (IV). The gene discussed is NF1; the disease is malignant peripheral nerve sheath tumor.