• Primary VS IC50 15 nM • Nf2-/- mouse schwannoma IC50 70 nM • NF2-/- Ben-Men-1 IC50 10 nM• Primary meningioma 25 nM • NF1-/- and NF1+/+ MPNST IC50 ≤ 70 nM. The gene discussed is NF1; the disease is malignant peripheral nerve sheath tumor.