• Primary VS IC50 250 nM (Cucurbitacin D) • Nf2-/- mouse schwannoma IC50 750 nM• NF2-/- Ben-Men-1 IC50 200 nM• Primary meningioma IC50 200 nM• NF1-/- ST8814 MPNST ~50 nM (cucurbitacin I). The gene discussed is NF2; the disease is schwannoma.