GSVA analyses also confirmed that the cell cycle pathway was more activated in PD-1hiCD8+ T cells compared with other exhausted CD8+ T cell subsets with PD-1 expression (melanoma: NES=2.07, p.adj=0.0059; NSCLC: NES=1.98, p.adj=0.0130). The gene discussed is CD8A; the disease is non-small cell lung carcinoma.