Our study is the first to highlight that anti-tumor lymphocytes (NK and CD8+ TRM cells, specifically CD8+ CD103- TRM cells) were decreased and immunosuppressive lymphocytes (Treg cells, specifically effector Treg cells) were increased in the MES T. These results indicate poor anti-tumor immunity in the MES T, which favors CRC development. Here, ITGAE is linked to neoplasm.